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ผลงานตีพิมพ์ในวารสารวิชาการAccumulation of domoic acid in marine organisms from Sriracha bay, Chonburi province, Thailandผู้แต่ง: Veschasit, O,  Dr.Shettapong Meksumpun, Professor , Thawonsode, N, Lirdwitayaprasit, T, วารสาร:  
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 ที่มา:TERPNET 2013: 11th International Meeting on Biosynthesis, Function and Biotechnology of Isoprenoids in Terrestial and Marine Organismsหัวเรื่อง:Genetic Modification of Soybean Saponins Showing Health Beneficial and Undesirable Taste Characteristics: Changes of the Composition and Content in Soybean Processed Foods |
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ที่มา:การประชุมทางวิชาการของมหาวิทยาลัยเกษตรศาสตร์ ครั้งที่ 48หัวเรื่อง:การคัดเลือกสารสกัดจากสิ่งมีชีวิตในทะเลที่สามารถกำจัดลูกน้ำยุงที่เป็นพาหะนำโรค |
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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Synthesis and Biological Evaluation of 3,16,20-Polyoxygenated Steroids of Marine Origin and Their Analogs) ผู้เขียน:สุธินี บุญอนันต์วงศ์, ดร.บุญส่ง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ , ดร.งามผ่อง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ สื่อสิ่งพิมพ์:pdf AbstractThe natural polyoxygenated steroids (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)- 16,20-dihydroxycholestan-3-one (2), (20S)-20-hydroxycholest-1-ene-3,16-dione (3) and (20S)-20- hydroxycholest-4-ene-3,16-dione (4), isolated from the gorgonian, Leptogorgia sarmentosa and unnatural analogs (5) (6), (12) and (13) were synthesized from tigogenin. Antitumor activity against three tumor cell lines (breast cancer, MCF 7, lung cancer NCI and oral cancer KB) was evaluated. Two compounds (3 and 4) containing ?,?-unsaturated ketone at ring A showed strong activity against NCI-H 187 (IC50 2.55, 4.35 ?g/ml) and moderate activity against MCF 7 and KB, the IC50 being in the range 12.69 – 19.55 ?g/ml whereas the analog quinone steroid 5 showed moderate activity against all tested cells. Compound 1 containing a keto group at C-3 and a hydroxyl group at C-16 showed moderate activity against NCI (IC50 17.84 ?g/ml), but was inactive against MCF 7 and KB, whereas compound 2 showed no activity against all tested cells. Cholestane (6) with dihydroxyl groups at C-3 and C-16 showed moderate activity against NCI-H 187 and KB the IC50 being in the range 10.22-11.04 ?g/ml, but was weakly active against MCF 7 (IC50 50.0 ?g/ml). The aromatic cholestane 13, the analog of 6 was strongly active against KB (IC50 4.69 ?g/ml), weakly active against MCF 7 (IC50 38.2 ?g/ml) and inactive against NCI-H 187 cell lines. Surprisingly compound 12 containing on unsaturated side chain was inactive with all tested cells. |
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Synthesis and Cytotoxicity Studies of Polyhydroxysterols and Their Sulfate Analogs) ผู้เขียน:Potjamarn Bunyathaworn, ดร.บุญส่ง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ, ดร.งามผ่อง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ สื่อสิ่งพิมพ์:pdf AbstractThe six new polyhydroxy steroids, 3?, 20(S)-dihydroxy-5?-cholest-24-ene (19), 3?, 20(S)- dihydroxy-5?-cholestane (20), 3?, 20(S), 24-trihydroxy-5?-cholestane (23), 2?, 3?, 20(S)-trihydroxy- 5?-cholestane (29), 2?, 3?, 20(S)-trihydroxy-5?-cholest-24-ene (31), 2?, 3?, 20(S), 24-tetrahydroxycholestane (37) and the sulfate derivative 21 were synthesized from tigogenin. Antitumor activity against two tumor cell lines (lung cancer NCI-H187 and oral cancer KB) was evaluated. Compound 23 containing trihydroxy groups at the C-3, C-20 and C-24 positions showed strong activity against both NCI-H187 and KB cells (IC50 2.11 and 5.39 ?g/mL). The 3, 20-dihydroxy steroid 19 showed strong activity against NCI-H187 (IC50 4.24 ?g/mL) but was weakly active against KB (IC50 39.12 ?g/mL) whereas the analog 20 which has a saturated side chain showed moderate activity against KB (IC50 20.51 ?g/mL) and was inactive against the NCI-H187 cell line. Surprisingly, the sulfate derivative of 20, compound 21, was inactive to both tested cells. Compounds 29 and 31, having vicinal dihydroxy groups in ring A at C-2, C- 3 as well as a hydroxyl group at the C-20 position, showed similar activity against NCI-H187 (IC50 9.08 and 9.59 ?g/mL) but for the KB cell, only 31 showed strong activity (IC50 10.14 ?g/mL) whereas 29 was inactive. The analogue compound 37, which has an extra hydroxyl group at C-24, was inactive against both tested cell lines. |
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